Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted Approaches
نویسندگان
چکیده
منابع مشابه
Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted Approaches
The first biofluid markers developed for Alzheimer's disease (AD) used targeted approaches for discovery. These initial biomarkers were directed at key protein constituents of the hallmark brain lesions in AD. Biomarkers for plaques targeted the amyloid beta protein (Aβ) and for tangles, the microtubule-associated protein tau. Cerebrospinal fluid levels of Aβ and tau have excellent diagnostic u...
متن کاملUrinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches
Mounting evidence suggests that whole grain (WG) intake plays an important role in chronic disease prevention. However, numerous human studies have failed to produce clear-cut conclusions on this topic. Here, a combination of non-targeted and targeted metabolomics approaches, together with kinetic studies, was used to investigate biomarkers of WG wheat intake and further explore the diet-diseas...
متن کاملExpanding the prion disease repertoire.
In 1982, Stanley Prusiner proposed that the infectious agent of transmissible spongiform encephalopathies (TSEs), a group of relatively rare neurodegenerative disorders that includes Creutzfeldt–Jakob disease and scrapie, lacks replicating nucleic acids and instead is composed primarily of a misfolded conformation of the prion protein, which he termed PrP (1). Originally, the “prion” hypothesis...
متن کاملTargeted and non-targeted approaches for complex natural sample profiling by GCxGC-qMS.
The present study examines the ability of targeted and non-targeted methods to provide specific and complementary information on groups of samples on the basis of their component distribution on the two-dimensional gas chromatography (GCxGC) plane. The volatile fraction of Arabica green and roasted coffee samples differing in geographical origins and roasting treatments and the volatile fractio...
متن کاملTargeted and non-targeted approaches for metabolite profiling in nutritional research
Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University’s research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2015
ISSN: 1664-2295
DOI: 10.3389/fneur.2015.00256